The study of the mammalian immune system offers many advantages to systems biologists. The cellular components of the mammalian immune system are experimentally tractable; they can be isolated or differentiated from in vivo and ex vivo sources and have an essential role in health and disease. For these reasons, the major effectors cells of the innate immune system, macrophages, have been a particular focus in international genome and transcriptome consortia. Genomescale analysis of the transcriptome, and transcription initiation has enabled the (...) construction of predictive models of transcription control in macrophages that identify the points of control (the major nodes of networks) and the ways in which they interact. (shrink)

One of Hume's most well-known works and a masterpiece of philosophy, A Treatise of Human Nature is indubitably worth taking the time to read.

Jacques Derrida's extensive early writings devoted considerable attention to "being as presence," the reality underlying the history of metaphysics. In Derrida on Being as Presence: Questions and Quests, David A. White develops the intricate conceptual structure of this notion by close exegetical readings drawn from these writings. White discusses cardinal concepts in Derrida's revamping of theoretical considerations pertaining to language--signification, context, negation, iterability--as these considerations depend on the structure of being as presence and also as they ground "deconstructive" reading. (...) White's appraisal raises questions invoking a range of problems. He deploys these questions in conjunction with thematically related quests that arise given Derrida's conviction that the history of metaphysics, as variations on being as presence, has concealed and skewed vital elements of reality. White inflects this critical apparatus concerning being as presence with texts drawn from that history--e.g., by Plato, Aristotle, Bacon, Hume, Kant, Whitehead. The essay concludes with a speculative ensemble of provisional categories, or zones of specificity. Implementing these categories will ground the possibility that philosophy in general and metaphysics in particular can be pursued in ways which acknowledge the relevance of Derrida's thought when integrated with the philosophical enterprise as traditionally understood. (shrink)

One of Hume's most well-known works and a masterpiece of philosophy, A Treatise of Human Nature is indubitably worth taking the time to read.

Do our lives have meaning? Should we create more people? Is death bad? Should we commit suicide? Would it be better to be immortal? Should we be optimistic or pessimistic? Since Life, Death, and Meaning: Key Philosophical Readings on the Big Questions first appeared, David Benatar's distinctive anthology designed to introduce students to the key existential questions of philosophy has won a devoted following among users in a variety of upper-level and even introductory courses.

Unpopular in its day, David Hume's sprawling, three-volume 'A Treatise of Human Nature' (1739-40) has withstood the test of time and had enormous impact on subsequent philosophical thought. Hume's comprehensive effort to form an observationally grounded study of human nature employs John Locke's empiric principles to construct a theory of knowledge from which to evaluate metaphysical ideas. A key to modern studies of eighteenth-century Western philosophy, the Treatise considers numerous classic philosophical issues, including causation, existence, freedom and (...) necessity, and morality. Unabridged republication of the edition originally published by Oxford at the Clarendon Press, London, 1888. (shrink)

In this book Berry provides a useful summary and comparison of the positions of Hegel and Hume on human nature and its relation to social diversity. After a general introduction, Berry discusses the Enlightenment, Herder’s reaction, Kant, then Hume and Hegel. Most of the comparisons of the latter two are made during the treatment of Hegel. For each thinker Berry asks about the unity of human nature and its relation to social diversity: What is the kind of unity (...) involved, what causes historical and social differences, and is history crucial to a study of human nature? Along the way various topics such as language and property are studied for their bearing on the more basic issues. Berry discusses the intellectual milieu of his two thinkers with respect to his themes; this provides useful background on the Enlightenment and Romantic conceptions, especially in Berry’s discussion of Herder’s reaction to the Enlightenment theories of an ahistorical human nature. (shrink)

A key to modern studies of 18th century Western philosophy, the Treatise considers numerous classic philosophical issues, including causation, existence, freedom and necessity and morality. This abridged edition has an introduction which explain's Hume's thought and places it in the context of its times.

Oxford Philosophical Texts Series Editor: John Cottingham The Oxford Philosophical Texts series consists of authoritative teaching editions of canonical texts in the history of philosophy from the ancient world down to modern times. Each volume provides a clear, well laid out text together with a comprehensive introduction by a leading specialist, giving the student detailed critical guidance on the intellectual context of the work and the structure and philosophical importance of the main arguments. Endnotes are supplied which provide further commentary (...) on the arguments and explain unfamiliar references and terminology, and a full bibliography and index are also included. The series aims to build up a definitive corpus of key texts in the Western philosophical tradition, which will form a reliable and enduring resource for students and teachers alike. David Hume's aim in writing An Enquiry concerning Human Understanding was to introduce his philosophy to a European culture in which many educated people read original works of philosophy. He gives an elegant and accessible presentation of strikingly original and challenging views about the limited powers of human understanding, the attractions of scepticism, the compatibility of free will and determinism, and weaknesses in the foundations of religion. Hume's philosophy was highly controversial in the eighteenth century and remains so today. The text printed in this edition is that of the Clarendon critical edition of Hume's works. A substantial introduction by the editor explains the intellectual background to the work and surveys its main themes. The volume also includes detailed explanatory notes on the text, a glossary of terms, a full list of references, and a section of supplementary readings. (shrink)

Essays by 13 contributors on the philosophical writings of Hume, Comenius, Kant, & Spinoza.

A scholarly edition of a work by David Hume. The edition presents an authoritative text, together with an introduction, commentary notes, and scholarly apparatus.

David Hume's Enquiry concerning Human Understanding is the definitive statement of the greatest philosopher in the English language. His arguments in support of reasoning from experience, and against the "sophistry and illusion"of religiously inspired philosophical fantasies, caused controversy in the eighteenth century and are strikingly relevant today, when faith and science continue to clash. The Enquiry considers the origin and processes of human thought, reaching the stark conclusion that we can have no ultimate understanding of the physical world, (...) or indeed our own minds. In either sphere we must depend on instinctive learning from experience, recognizing our animal nature and the limits of reason. Hume's calm and open-minded skepticism thus aims to provide a new basis for science, liberating us from the "superstition" of false metaphysics and religion. His Enquiry remains one of the best introductions to the study of philosophy, and his edition places it in its historical and philosophical context. (shrink)

Do our lives have meaning? Should we create more people? Is death bad? Should we commit suicide? Would it be better if we were immortal? Should we be optimistic or pessimistic? Life, Death, and Meaning brings together key readings, primarily by English-speaking philosophers, on such 'big questions.'.

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

David and Mary Norton present the definitive scholarly edition of Hume's Treatise, one of the greatest philosophical works ever written. This set comprises the two volumes of texts and editorial material, which are also available for purchase separately. David Hume is one of the greatest of philosophers. Today he probably ranks highest of all British philosophers in terms of influence and philosophical standing. His philosophical work ranges across morals, the mind, metaphysics, epistemology, religion, and aesthetics; he (...) had broad interests not only in philosophy as it is now conceived but in history, politics, economics, religion, and the arts. He was a master of English prose. The Clarendon Hume Edition will include all of his works except his History of England and minor historical writings. It is the only thorough critical edition, and will provide a far more extensive scholarly treatment than any previous editions. This edition offers authoritative annotation, bibliographical information, and indexes, and draws upon the major advances in textual scholarship that have been made since the publication of earlier editions - advances both in the understanding of editorial principle and practice and in knowledge of the history of Hume's own texts. (shrink)

David and Mary Norton present the definitive scholarly edition of Hume's Treatise, one of the greatest philosophical works ever written. The first volume contains the critical text of David Hume's Treatise of Human Nature (1739/40), followed by the short Abstract (1740) in which Hume set out the key arguments of the larger work; the volume concludes with A Letter from a Gentleman to his Friend in Edinburgh (1745), Hume's later defense of the Treatise.

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

This is the first new scholarly edition this century of one of the greatest works in the history of philosophy, David Hume's Enquiry concerning Human Understanding. It is the third volume of the Clarendon Hume Edition, which will be the definitive edition for the foreseeable future. In this work Hume gives an elegant and accessible presentation of strikingly original and challenging views. The distinguished Hume scholar Tom Beauchamp presents an authoritative text accompanied by an introduction, (...) annotation, a glossary, biographical sketches, bibliographies, and indexes. (shrink)

Long before the current dispute in the USA about the teaching of evolution, Hume's dialogues presented and critically analyzed the idea of intelligent design. What should we teach our children about the creation of the world? What should we teach them about religion? The characters Demea, Cleanthes, and Philo passionately present and defend different answers to that question. Demea opens the dialogue with a position derived from René Descartes and Father Malebranche — God's nature is a mystery, but God's (...) existence can be proved logically. Cleanthes attacks that view, both because it leads to mysticsm and because it attempts the impossible task of trying to establish existence on the basis of pure reason, without appeal to sense experience. As an alternative, he offers a proof of both God's existence and God's nature based on the same kind of scientific reasoning established by Copernicus, Galileo, and Newton. Taking a skeptical approach, Philo presents a series of arguments that question any attempt to use reason as a basis for religious faith. He suggests that human beings might be better off without religion. The dialolgue ends without genuine agreement among the characters, justifying Hume's choice of dialogue as the form of presentation. (shrink)

David Hume (1711-76) is the grand intellectual figure of the Scottish Enlightenment. Ironically, what is now considered his magnum opus, the ill-received three-volume A Treatise of Human Nature (1739-40), was rejected by Hume himself by 1751. Subsequently, when Hume first compiled his Essays and Treatises on Several Subjects two years later, he excluded the Treatise and considered this new collection of essays to be his complete philosophical writings. Hume revised the Essays and Treatises some ten (...) times in various editions, adding, modifying and deleting material. This 1777 edition incorporates his final changes which he made quite literally on his deathbed, fully aware that this edition would be the last to involve his input. As such it is considered the definitive edition of Hume's philosophical writings and should be read alongside the first definitive edition of the Treatise. (shrink)

How do we know that God exists? One of Britain's greatest 18th-century philosophers addresses the age-old question in this timeless dialogue. Equally captivating as a philosophical argument and as a work of literature, this classic is particularly relevant in terms of its criticism of the reasoning behind Intelligent Design.

"A facsimile reprint of a letter written by the philosopher and historian David Hume in 1744 in defence of his views on ethics, in which he argues that a critique of the logic of a philosophical stance is not a general attack on the ethics of that position." --.

Tom Beauchamp presents the definitive scholarly edition of two famous works by David Hume, both originally published in 1757. In A Dissertation on the Passions Hume sets out his original view of the nature and central role of passion and emotion. The Natural History of Religion is a landmark work in the study of religion as a natural phenomenon. Authoritative critical texts are accompanied by a full array of editorial matter.

Tom Beauchamp presents the definitive scholarly edition of two famous works by David Hume, both originally published in 1757. In A Dissertation on the Passions Hume sets out his original view of the nature and central role of passion and emotion. The Natural History of Religion is a landmark work in the study of religion as a natural phenomenon. Authoritative critical texts are accompanied by a full array of editorial matter.

In a final, short summary of his life and works, David Hume wrote My Own Life as he suffered from gastrointestinal issues that ultimately killed him. Despite his bleak prognosis, Hume remains lighthearted and inspirational throughout. He discusses his life growing up, his family relationships, and his desire to constantly improve his works and his reputation as an author. He confesses, "I have suffered very little pain from my disorder; and what is more strange, have... never suffered (...) a moment's abatement of my spirits; insomuch that were I to name the period of my life which I should most choose to pass over again, I might be tempted to point to this later period." This short biography ends with a series of letters from Hume's close friend and fellow author Adam Smith to their publisher William Strahan, recounting Hume's death and giving a stirring eulogy in honor of their friend. (shrink)

• If we always see b after a, we are justified in thinking b will follow a the next time we see a. • “A hundred instances or experiments on one side, and fifty on another, afford a doubtful expectation of any event; though a hundred uniform experiments, with only one that is contradictory, reasonably beget a pretty strong degree of assurance” (74).

David Hume’s An Enquiry Concerning Human Understanding, first published in 1748, is a concise statement of Hume’s central philosophical positions. It develops an account of human mental functioning which emphasizes the limits of human knowledge and the extent of our reliance on (non-rational) mental habits. It then applies that account to questions of free will and religious knowledge before closing with a defence of moderate scepticism. This volume, which presents a modified version of the definitive 1772 edition (...) of the work, offers helpful annotation for the student reader, together with an introduction that sets this profoundly influential work in its philosophical and historical contexts. The volume also includes a selection of other works by Hume that throw light on both the circumstances of the work’s genesis and its key themes and arguments. (shrink)

David Hume's Dialogues concerning Natural Religion, first published in 1779, is one of the most influential works in the philosophy of religion and the most artful instance of philosophical dialogue since the dialogues of Plato. It presents a fictional conversation between a sceptic, an orthodox Christian, and a Newtonian theist concerning evidence for the existence of an intelligent cause of nature based on observable features of the world. This new edition presents it together with several of Hume's (...) other, shorter writings about religion, and with brief selections from the work of Pierre Bayle, who influenced both Hume's views on religion and the dialectical style of the Dialogues. The volume is completed by an introduction which sets the Dialogues in its philosophical and historical contexts. (shrink)

In his writings, David Hume set out to bridge the gap between the learned world of the academy and the marketplace of polite society. This collection, drawing largely on his Essays Moral, Political, and Literary, which was even more popular than his famous Treatise of Human Nature, comprehensively shows how far he succeeded. From `Of Essay Writing' to `Of the Rise and Progress of the Arts and Sciences' Hume embraces a staggering range of social, cultural, political, demographic, (...) and historical concerns. With the scope typical of the Scottish Enlightenment, he charts the state of civil society, manners, morals, and taste, and the development of political economy in the mid-eighteenth century. These essays represent not only those areas where Hume's arguments are revealingly typical of his day, but also where he is strikingly innovative in a period already famous for its great thinkers. ABOUT THE SERIES: For over 100 years Oxford World's Classics has made available the widest range of literature from around the globe. Each affordable volume reflects Oxford's commitment to scholarship, providing the most accurate text plus a wealth of other valuable features, including expert introductions by leading authorities, helpful notes to clarify the text, up-to-date bibliographies for further study, and much more. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

O texto a seguir, intitulado “Ensaio Histórico sobre a Cavalaria e a Honra dos Modernos”, foi escrito durante a juventude de David Hume, certamente antes da publicação do Tratado da Natureza Humana. Ainda não há consenso inabalável sobre o ano em que esse ensaio foi produzido. John Hill Burton, que o publicou pela primeira vez, em 1846, considera que Hume o teria escrito em 1727, logo após deixar o Edimburgh College. J. Y. T. Greig propõe uma conjectura (...) um pouco mais, por assim dizer, elástica, considerando que o texto deve ter sido escrito no período de 1729 a 1734. (shrink)